pertwk Chapter 331 Apply For Teaching!
Chapter 331 Apply For Teaching!
Song He conveniently opened a new program to simultaneously reproduce the drug prediction process based on the data from Irema Laboratory.
He didn't dare to accept all the results of others, so it was better to verify them himself!
The first is the prediction of classic DDIs, that is, drug-drug interactions, which explore the compound effects produced by patients taking multiple drugs in a short period of time.
In the laboratory of Jinghai University, Lu Chengen talked about the five principles of traditional Chinese medicine prediction, which are opposites to control, fear of each other to control, happiness to control each other, mutual support to control, and dislike to control each other. These are also the principles of drug-drug interaction, but Modern DDIs predictions go deep into the molecular level.
When Song He read related papers before, he saw DDIs predictions based on graph convolutional neural networks and predictions based on balance theory.
The former is too one-sided and only considers the adjacency matrix elements. The latter is too absolute. In summary, "friends of friends are friends" and "friends of friends are enemies." However, in actual drug development, the relationship is far more complicated than the balance theory.
On the computer screen, Irema Laboratory actually abandoned both methods and used a new method to predict DDIs!
Song He studied for a long time and basically understood the idea... big database derivation!
The Irema laboratory attempts to expand the massive number of compounds, sort out their relationships, and draw a spectacular tree diagram, with each branch connected to a similar compound.
Then, based on the identified medicinal properties of the compounds, we can boldly guess the medicinal effects of the unknown compounds.
It's like knowing that your husband is a biologist and your wife is a sprinter, so you guess that the couple's future grandson will be able to... sprint while holding a microscope to observe bacteria...
In essence, it is still a random guess about the drug, but there is a hint of far-fetched reasoning in the guess.
"It's so difficult!" Song He complained.
He searched for the large database used by Irema's laboratory in the post.
After searching for a long time...can't find it?
"No wonder! It turns out that only marginal data was released, and the core data was not released!" Song He shook his head and laughed.
He had no choice but to try to collect the database himself.
He first searched online for scientific research teams that had used similar working methods.
It took a long time to find two in total.
One is a research and development team working with Qiandu. Through a large amount of esophageal cancer patient data, they found 22 significantly mutated genes, and then predicted and associated feasible drug information.
One is MSK Cancer Center, which has developed a knowledge base related to somatic mutations and includes a large number of targeted drugs.
"These are all cancer databases, so they are useless!" Song He scratched his head.
After thinking about it, he took out his mobile phone and asked Teacher Xiang Xiaotong for help outside the court.
"Teacher, I need a large database related to sleeping pills for drug prediction. Do you know where I can get it? Thank you very much, student!"
As soon as he sent the message, Song He immediately regretted it. In the middle of the night, would it disturb the teacher's rest?
Unexpectedly, after a few seconds, the reply came.
Xiang Xiaotong: "I know that Professor Tan Xi's team has built a database of sleeping pills, but Tan Xi is too narrow-minded to provide it to you."
Xiang Xiaotong: "Let's do this. I have a hacker in my team who will help you get some relevant data online. I'm not sure how much I can get. You can use it as a reference."
Song He quickly replied, "Thank you, teacher! The students simply don't know how to thank you!"
Xiang Xiaotong: "When you learn brain skills from me later, just work hard."
An hour later, Xiang Xiaotong threw in a large number of data files.
Song He opened it and saw that every document was huge!
There was a huge amount of messy data, including the compound analysis he wanted, as well as strange and useless data. Most of it came from databases of medical organizations around the world, and all kinds of strange languages were gathered together. It would take a long time just to translate it on a computer.
If I were to do it alone, just sorting out these data would probably have to wait until the Chinese New Year!
Song He sighed deeply. It seems that this time he must hire an experimental team to make short-sleeping pills!
Unlike military crater explosives, sleeping pills are mainly of commercial value, so there is no need to maintain tight confidentiality. Just recruit some reliable people to do the work and pay attention to the division of labor.
Song He learned an effective method of keeping secrets secret in counterintelligence textbooks, the blind man and the elephant method.
This method is commonly used in large projects. The staff are divided into groups. Each group is only responsible for a small part of the operation. It is strictly forbidden to exchange messages between the groups.
As a result, everyone involved in the matter can only understand a small part of the situation in front of them, and cannot know the whole picture of the entire project. Even if individual spies sneak in, the information stolen is far from enough to damage the overall situation, and may even be misleading. Information.
It's a bit like the watertight compartments in a warship. There are many compartments that are not connected to each other. Even if one or two compartments are hit by fish and flooded, the other compartments will be intact and the ship will still be able to remain unsinkable.
The plan is wonderful.
But where to hire the manpower?
…
Aerospace Town, third floor of the General Affairs Building.
Office No. 1.
Song He sat alone at the table, tapping his fingers on the table at a steady pace and waiting.
The door to the room suddenly opened, and Tang Rongrong appeared in a white down jacket with a sleepy face, "Handsome, do you have to do business in the middle of the night?"
"Thank you." Song He handed over a purple ID card.
Tang Rongrong's sleepiness disappeared halfway, "Have you been promoted to level II? So fast! What kind of business are you doing?"
"I want to start a class." Song He said, "I don't have an application form in my hand. Give me one and I'll fill it out now."
Tang Rongrong moved quickly, opened the desk drawer, took out an application form and handed it over, and offered a gel pen.
Song He filled in the entire form from beginning to end.
[New course name: Drug R&D Analysis]
[Maximum number of students: 80 people]
[Requirements for students: Excellent mathematical ability, preference will be given to those with knowledge of biology]
[Class times: the first two periods in the morning every day, 7 days in total]
[Lecturer information: Song He, Level II project leader, Song Hesu inventor]
[Reason for applying for the course: Select a group of talents who are interested in drugs and have excellent qualifications, and join the short-term sleep drug development team after training]
[Main content of the course: Drug prediction and new drug development]
After filling in a lot of trivial information, Song He pushed the application form to Tang Rongrong.
"Okay!" Tang Rongrong typed on the screen, "The application has been submitted, and the approval results will probably come out at dawn. The first is to determine whether your course can be opened, and the second is to determine how many points are authorized for you."
"Do I get points for giving lectures?" Song He asked.
"On the one hand, it's the points you get from your lectures, and on the other hand, it's the students who take your course. How many points will the students get after the course."
Song He nodded, points are important.
The selection process has entered an intense stage, and everyone is rushing around to score points. How many points a course is worth has become the most critical course selection criterion!
Especially compared with other academic leaders who are starting courses, Song He knows very well that he is underrepresented. If the course score is not high enough, there may be very few students after the course starts, and he will not be able to select a qualified experimental team.
If you make one wrong step and fail to select enough people, it will be fatal to the progress of the research and development of short sleeping pills!
"Let me remind you, you have to be mentally prepared!" Tang Rongrong said.
"How do you say this?" Song He frowned slightly, "Do you think the courses I applied for will not be approved?"
Tang Rongrong opened the drawer, took out another declaration form, and placed it on the table.
Song He glanced at it and frowned instantly.
Internal competitor, Professor Tan Xi’s new course application form!
The teaching direction is clearly "Pharmaceutical Comprehensive Medicine", and it is obvious that he is also recruiting people to expand his team!
"This form was sent by Professor Tan Xi a few hours ago. If nothing else, the courses you both applied for will be approved at the same time." Tang Rongrong said, "He is the leader of the Level III project, and you only have Level II!"